What is truly remarkable is that in the Hashimoto’s thyroiditis group, the infection-fighting cells responded even more significantly to the supplementation of myo-inositol and selenomethionine compared to the control group. Tissue samples of lymphocytes were exposed to hydrogen peroxide as the source of oxidative stress. There were measurements taken before the use of the supplements and again after supplementation with myo-inositol alone, selenomethionine alone or a combination of myo-inositol and selenomethionine. The first study I’d like to cover on inositol, selenium, and Hashimoto’s disease came out of Italy in 2017 by Nordio and Basciani. Selenium also plays a huge part in the synthesis and function of thyroid hormones. It has antioxidant and anti-inflammatory properties and has been shown in previous investigations including those headed by Gartner et al.

The problem was that I don’t eat a lot of grains because, well, they make you fat, and I also didn’t know exactly how much inositol I was taking. I knew from reading countless studies that the sweet spot seemed to be about 50-60mg a day, so I started looking for a supplement. As I briefly mentioned earlier, one of the most talked about inositol benefits is how it benefits your hair. It’s a member of the B complex family which, as anybody who has studied will know, are known to promote strong hair, healthier hair, and faster growth. Early research shows that inositol might help control panic attacks and fear of public places or open spaces .

These compounds are also known as pseudovitamins as they share their structure with the B family of vitamins. When the term “inositol” is used as a dietary supplement, it usually refers to myo-inositol, unless otherwise stated. Starting October 2012, the US Department of Agriculture has not set a daily recommended allowance for this nutrient, nor is Inositol considered an essential nutrient. The nutrient can also be found in some vegetables and cereals in the form of Phytic acid.

  • Medication alone can often not help lower a high VLDL level, because VLDL also increases the size of LDL.
  • There have been at least 14 high-quality human trials testing the benefits of inositol for PCOS.
  • My husband and I were married in 2005 and tried to conceive for years.
  • The effects of arginine and silicon on joint health and connective tissue metabolism in mammals are well documented, and the ASI complex has been shown to benefit bone and vascular health .
  • Those that experience restlessness while taking inositol are more likely to have a preexisting psychiatric condition and/or be taking other meds that could provoke restlessness or interact with inositol to cause restlessness.
  • Caffeine lowers the levels of Inositol in the body, therefore patients who choose to follow this form of treatment should cut down on their daily intake of caffeine or preferably eliminate it from their diets altogether.
  • For this study, 20 women with PCOS were given either a placebo or 6 grams of D-chiro-inositol once daily for six to eight weeks.
  • Before we discuss the benefits are as they relate to testosterone, let’s take a look at other things that Inositol may have a positive influence on.
  • Even tryptophan-rich foods like yogurt and eggs can boost niacin levels.
  • Although the mechanism of action remains unclear Inositol hexanicotinate is safe and is effective in reducing the vasospasm of primary Raynaud’s disease during the winter months.
  • Increased myo-inositol levels can signal the beginning of a cognitive decline in inflammatory brain diseases, Alzheimer’s disease, and HIV.
  • I recommend taking 700 mg daily of the Rootcology Myo-Inositol Powder, which contains the myo-inositol form of inositol, for reducing TSH and thyroid antibodies .
  • Various other hormones and hormone-like substances bring about their effects by similar actions.
  • None of the research studies suggest that they were used together and it may cause your blood sugar to drop too much.
  • It is also believed that choline deficiency may contribute to cognitive decline such as memory loss as we age.
  • In my research of Inositol, I’ve read that it significantly lowers Testosterone levels in women, decreasing it up to 55% in some situations.
  • It lowers and regulates your body’s histamine level, which is the way it keeps cholesterol low and may also assist in proper cognitive functioning.

I forgot to mention I’m also taking vitamin D, calcium and folic acid, I’m taking citalopram for my moods and spironolactone for extra hair. The gut microbiome has been found to be critical to insulin/glucose regulation. Low grade generalized inflammation in fat tissues or in the liver is an important factor in insulin resistance, a condition common to PCOS.

The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. Inositol powder supplements have very rare and minimal side effects. Known side effects are limited to only minor stomach upset when a high dose is involved. More evidence is needed to rate the effectiveness of inositol nicotinate for these uses. Problem solving ability and concentrate can also improve from the Choline. Choline is necessary for the functioning of the brain, for the synthesis of neurotransmitters and for the creation and maintenance of the membrane of brain cells .

I didn’t change the type, dosage or anything else of the inositol; I just added magnesium. Great article Gloom, you’ve created a valuable resource with this site, and I really appreciate your research! @FoxBader, if you’re reading this, thanks for your valuable and extensive comment, I found that useful. I have been experiencing anxiety on and off my whole life, and depression too, but more recently I’ve been dealing with a LOT of intrusive OCD type thoughts. Eventually I learned to cope, and found that breathing techniques and exercise helped tremendously to where I would have ~6 months to a year between attacks. Approximately 2 months ago, I had a severe panic attack, in which I had a heart rate of 173 for several minutes, went to ER, cardiologist, neruologist, and SVT and other serious issues were ruled out.

We naturally can increase our intake of IP6 by consuming the outer layer of grains , but soybean seed is the best source with its whole seed containing up to 26% of IP6. Inositol may help to improve the texture and condition of the hair. It is often attributed to helping improve the appearance of the hair and potentially repairing damage. Healthline may be its ability to help protect the skin from sun damage. One study also suggested that it may play a role in supporting collagen production.

At least moderate severity of anxiety symptoms as determined by score of ≥ 13 on the Pediatric Anxiety Rating Scale . All the vitamins from the B complex are water soluble sothey cannot be stored in the human body. Inositol is a vital part of theprocess of the formation of lecithin. FactDr does not provide medical opinion, advice, diagnosis or treatment. Inositol or cyclohexane, is a chemical compound with formula, a sixfold alcohol of cyclohexane. It exists in nine possible stereoisomers, of which the most prominent form, widely occurring in nature, is cyclohexanehexol.

No-flush niacin is formulated from the combination of six molecules of nicotinic acid and one molecule of inositol. This special niacin formulation acts as a vasodilator and it is also meant to slowly release nicotinic acid. Therefore, it opens up the blood vessels to improve blood flow and avoid the spike in the blood niacin level as well as the “flushing” that accompanies the spike. In fact, inositol supplements are rarely used to lower cholesterol. Instead, a complex of niacin and inositol is actively marketed as a cholesterol-lowering supplement. Therefore, inositol may have other cardiovascular benefits besides its effect on cholesterol levels.

The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. There are few if any side effect risks from taking inositoleven at high doses. In extreme cases way beyond the recommended dose, nausea is possible but is still rare.

Inositol can even aid postmenopausal women, by lowering serum triglyceride levels and increasing “good” cholesterol, otherwise known as high-density lipoprotein. I was on Metformin for almost 2.5 years with no change in my cycles and/or ovulation. I started Vitex and it helped some – I had a cycle maybe every 3 or 4 months but no ovulation. I started Myo-inositol and in less than 2 months I started having a regular cycle and ovulating. I also found that weight loss was another added bonus from taking the Myo-inositol – I’ve lost almost 60 lbs since starting this supplement. I’m happy to say after about 7 months on Myo-inositol I found out I was pregnant.

New research finds it may also be a great way to improve egg health for all women . There is a presence of inositol and IP1-6 in gastric epithelial cells as early as within 1 h of intragastric 3H- IP6 administration. The metabolized IP6, in the form of inositol and IP1 is transported via plasma and reaches distant organs as well as tumors. However, in humans 1-3% of total administered IP6 is excreted in the urine as IP6. Investigations of the uptake and metabolism by a variety of cancer cell lines in vitro also demonstrate an instantaneous absorption of IP6. The rate and pattern at which IP6 is metabolized by cancer cells varies depending on the cell type.

Inositol Subtype

Myo-Inositol can be converted to D-chiro-inositol in the body (D-chiro-inositol is one of the 9 isomers along with myo-inositol). So, supplementing with either one should be effective in managing some of your PCOS symptoms. If that’s correct, would I be able to stop taking them if i start on one of the inositol supplements you mentioned?

It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content.

Even at high doses, side effects are mainly limited to nausea, gas, and diarrhea. Inositol used to be thought of as an essential nutrient, which is any nutrient that must be obtained from your diet. However, observations have shown that the liver and kidneys produce inositol from glucose, so it’s not an essential nutrient. In general, a good-quality research report needs 1-3 months to be finished.

Inositol: Do The Benefits Outweigh The Side Effects?

Getting inadequate amounts of choline may also lead to inflammation, which can lead to a number of diseases, including cancer and diabetes. I’ve Are 3000mg CBD Gummies suitable for beginners? only noticed crazy nightmares, restlessness, and sometimes extremely tired. I might need to cut back on the 4mg, but the weight loss is great!

The Major Sources Of Inositol

These dosages do not provide brain boosting benefits for the majority of people, but are appropriate for a daily multivitamin use. Food products that are rich in Choline include egg yolks, liver, spinach, wheat germ, beans, nuts, and fish. Choline Bitartrate is the type of choline that can be usually bought in the supplement stores, but you can also purchase Choline Citrate as well.

If you’re taking inositol to help with your fertility then it would be smart to also take folic acid at 400 mcg daily. Always discuss the use of supplements with your healthcare provider first if you have any concerns at all. Your body can also naturally produce inositol from the carbohydrates you eat, although, research suggests that additional inositol in the form of supplements may have numerous health benefits.

Benefits Of Using Inositol

These days, there’s no shortage of performance-enhancing supplements to choose from. Nitrosigine® is one the newer kids on the block, and has quickly made a name for itself as a powerful way to improve performance. It’s one supplement worth getting to know when you want to take your workout to the next level. The activated PtdOH phosphatase directs biosynthetic flux away from CDP-DG and PtdIns, and so dictates that the nuclear envelope lipid bilayer contains less PtdIns than the ’bulk’ ER. Mammalian cells are typically quoted as having ~10 % of their membrane phospholipid as PtdIns.

Other Health Benefits Of Inositol

Inositol itself may have a therapeutic effect on the nerve diseases associated with diabetes. Some scientists consider it the best remedy for relieving stress, relieving patients of tension and anxiety, and sleeping pills. Studies show that inositol allows the balance of copper and zinc in brain cells, which is important for our nervous system. Too much copper in the brain cells can cause irritability, bothersome neurosis, aggressiveness and even mental anomalies. The presence of inositol corrects this surplus, and zinc balances adverse effects and brings relaxation. Benefits of GingerThere are a number of health benefits of ginger as this powerful herb has been shown to relieve migraines and nausea, reduce cancer risk, and much more.

Premenstrual Dysphoric Disorder Pmdd

Inositol levels are lower than normal in people with depression. We provide links to products that we think can help you achieve better brain health and performance. We earn revenue when you buy through our links, at no extra cost to you.

Enrichment And Interrogation Of Cancer Stem Cells

Mental Health – at adequate dosages, inositol may have an anxiolytic effect, reducing symptoms of anxiety and depression. Male Fertility – a natural consequence of improved sperm quality is enhanced male fertility, one of the key reasons to supplement inositol. This is why the combination of inositol and antioxidants has increasingly become a popular strategy in improving male health and fertility. Through insulin-sensitizing, anti-inflammatory, and antioxidant mechanisms, inositol, in conjunction with antioxidants, may help support male sexual health and metabolism. In truth, inositol is a carbocyclic sugar that’s structurally similar to glucose, the body’s primary food fuel for producing ATP energy, the body’s primary unit of cellular energy.

Inositol Dosage

Choline and inositol can be found in foods and are also available in supplement form. While they’re both crucial for building cell membranes and regulating cellular activity, they also have individually unique roles. Currently, there is no official recommended daily intake of Inisitol dosage for hair loss, but in general, people seem to take about 2 mg to 4 mg to treat their thinning hair. Now is a well-known natural supplement company that has been around for 40 years.

What Is The Function Of Inositol?

Each bottle is a one month supply, and the daily dosage is 4 capsules. There is no harm taking them all at once in the morning or in divided doses throughout the day with food. SOURCES OF INOSITOLBrewer’s yeast, lecithin, meats, milk, vegetables, and grains supply inositol. Nuts, seeds, beans, whole grains, cantaloupe, and citrus fruits supply a substance called phytic acid, which releases inositol when acted on by bacteria in the digestive tract. There are no specific indications for inositol supplementation in dogs and cats.

The usual dosage for anxious disorders ranges between 12 and 18 grams. One of the depression studies used just 6 grams, but I haven’t found any research suggesting that it works neurologically at doses any lower than that. In one study, patients with OCD took 18 grams of inositolor placebo daily for six weeks. Many patients with panic disorder and agoraphobia don’t respond well to current treatments, or they discontinue drugs because of their side effects. And people with bipolar disorder who were going through a major depressive episode supplemented with inositol for six weeks, and it led to a 17.4% reduction in their depressive symptoms . But you don’t need to do tDCS to increase inositol levels in the brain.

When combined with folic acid, inositol can improve insulin levels, as well as lower the triglyceride levels in the blood. Above all, this combination is also powerful when it comes to improving ovulation in women with fertility problems. According to the research, combining inositol and folic acid for three months improved the ovulation in 62% of female patients. The primary purpose of inositol is to transport fat throughout the human body and regulate blood sugar. As it also influences serotonin and dopamine, this natural substance serves as an outstanding cognitive and mood enhancer as well. According to studies conducted so far, it is especially effective when used by women, relieving the symptoms of PCOS, anxiety, PMS, and binge eating.

Food Sources

As mentioned before, inositol hexanicotinate has 6 molecules of niacin attached to one molecule of Inositol that are broken down and released into the blood stream. This break down or hydrolysis of inositol hexanicotinate into separate Niacin and Inositol molecules happens at a very slow rate. Inositol causes the metabolism of Niacin molecules to slow down, thereby causing the peak effect of Inositol hexanicotinate on the blood cholesterol to actually occur hours after drug intake.

For the second month of treatment, the 20 patients received fluvoxamine at a dosage of 150 mg per day. There are some possible drawbacks associated with inositol as Is delta 8 federally legal? a treatment for anxiety disorders. The biggest drawbacks are that its efficacy is questionable and that high-dosages are typically required for therapeutic relief.

Although it is not possible to develop IP6 and IS6 themselves as anti-AIDS drugs, studies of these anti-HIV agents might be expected to provide seed for eventual production of superior drugs for AIDS treatment. A preliminary investigation did assess the efficacy of DCI, myo-inositol, manganese and folic acid supplementation in the second trimester of pregnancy. We can safely deduce from this study that since it assessed efficacy in pregnant women, it is really okay to take DCI during pregnancy. We still do not know whether DCI is safe during pregnancy or breastfeeding, since no clinical trials have been done on that till date. But since it is a compound that plays a crucial role in a vital activity, there is no reason to believe that it cannot be safe to take in the form of a supplement when the body is unable to make it in sufficient amounts. It has also been found that women with Polycystic Ovarian Syndrome, or PCOS, have low levels of DCI.

I started taking Inositol about a month ago and I have noticed some positive benefits, but as I read more about it’s effects on decreasing testosterone and increasing estrogen in men I don’t know if it’s for me. Inositol is available both as a separate supplement containing myo-inositol and choline, and as a component of lecithin supplements. Although the consumption of large amounts of caffeine may How long will CBD Gummies stay in my body? cause a shortage of inositol in the body, deficiencies of choline are rare. Nevertheless, heavy coffee drinkers should probably consider taking supplemental inositol. Inositol helps maintain healthy skin by preventing and treating eczema, a skin disease characterized by swelling and inflammation. Improvements in respiration have been seen in newborn babies who are having difficulty breathing.

As with all supplements it is important to find the correct dosage and to implement the supplement safely into your routine. Dosage amounts for theanine should be based on personal response but as always refer to your packaging for more information, a safe bet would to be stay under the 1000mg mark. The best dosage for most people with insomnia is to take 2 grams of inositol powder in water before bed. Inositol hexaphosphate is also known as IP6, myo-inositol hexaphosphate, or phytic acid.

These include headaches and flushing – where the skin gets itchy, red and warm – within a few minutes of consumption. Other side effects could be elevated liver enzymes, reduced glucose tolerance, palpitations and gastrointestinal upset. While flushing is not entirely harmful, many people find these occurrences highly uncomfortable and are put off from taking their daily dosage to avoid experiencing a flush. An alternative for such people is inositol hexanicotinate with which the side effects of Niacin are reduced to a great extent.

Inositol Review: Benefits For Male Health

It is important to first note the study found absolutely no side effects. Unfortunately, they did not find conclusive evidence to support inositol as an effective treatment for individuals with symptoms of depression. Results noted that severity of panic disorder significantly declined among those receiving inositol compared to those receiving the placebo. Additionally, researchers noted that side effects associated with inositol were minimal and that it may be an appealing therapeutic option for the treatment of panic disorder. This provides additional evidence that inositol is likely an effective anti-panic agent with anxiolytic properties. Authors propose that inositol may be effective in treating related psychiatric conditions responsive to SSRIs (e.g. depression and panic disorders).

Zazzee Naturals is a natural supplement producer currently in the midst of rebranding. Puritan’s Pride Inositol provides a potent inositol dosage in vegetarian capsules. This inositol pill provides a good dosage in a vegetarian capsule and is made in the USA in a GMP-certified facility. However, the company that produces it specializes in Asian Pacific herbal supplements, and there are few reviews on the product. Source Naturals is a vitamin and herbal supplement provider founded in 1982.

You can really improve your symptoms and fertility by making some changes in all of these areas. Recent research has also shown that diet and lifestyle changes can be more effective than medication anyway. Birth control can help to regulate your cycle as well as manage your testosterone levels . Recent research has shown that women who take BCP and Inositol have better insulin and testosterone levels with better overall improvement in their symptoms. Inositol is often myo-inositol (with Inositol being it’s common name). D-chiro-inositol is another form of myo-inositol that the body can produce from myo-inositol.

This is a high-quality inositol supplement offering a potent dosage. The company is so confident in the quality that it offers a money-back guarantee. Pure Encapsulations Inositol Powder offers pure, potent inositol doses of 4.1 grams per serving. This powder is high quality and hypoallergenic and mixes well in water or other liquids. This is a good inositol supplement blended with choline, made by a good brand with a reputation. It is affordable, vegetarian and free from many allergens, but it does contain some additional ingredients.

You might also enjoy: